Shanghai Rechem Science Co., Ltd.
Business Type:Trader
Country/Region:China
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HOT Rank
Shanghai Rechem Science Co., Ltd.
We are professional supplier of Inhibitors,Agonists,Active micromolecule.
Shanghai Rechem Science Co., Ltd.
We are professional supplier of Inhibitors,Agonists,Active micromolecule.
Business Type:Trader
Country/Region:China
Ddu Verified
HOT Rank
Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.
Eliglustat tartrate shows good potency with an IC50 of 24 nM and specificity against the target enzyme. Incubating K562 or B16/F10 cells for 72 h with increasing amounts of Genz-112638 (0.6-1000 nM) results in a dose-dependent reduction of cell surface levels of both GM1 and GM3. The mean IC50 value for inhibiting the cell surface presentation of GM1 in K562 cells was 24 nM (range 14-34 nM) and that for GM3 in B16/F10 cells was 29 nM (range 12-48 nM).